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As negative regulators of the mTORC1 pathway (Budanov and Karin, 2008), sestrins bind and inhibit GATOR2 (Parmigiani et al., 2014), a positive regulator for nutrient-sensing of this pathway, under leucine deprivation

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In addition, the large surface of proteins involved in the interaction among proteins is not covered by small molecules because their sizes are too small 124

Anti-Inflammatory Effects Chronic inflammation is a common denominator in many diseases, including skin conditions like acne and eczema

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