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Under normoxic conditions, p53 directly limits glucose uptake by repressing the transcription of GLUT1 and GLUT4, and induces TIGAR expression, thereby reducing PFK1 activity

Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase

Similarly, NADP + is synthesized through various intracellular pathways, including the pentose phosphate pathway and NAD + kinases [145]

Y., Yue, G

doi: 10.1016/j.humpath.2017.12.005 [DOI] [PMC free article] [PubMed] [Google Scholar] 119.Khan KN, Fujishita A, Koshiba A, et al

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