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Moreover, STF-31 treatment abolished the metformin-induced glucose excretion in both cell lines (Fig

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This adverse effect can be prevented by prior treatment with mesna (mercaptoethane sulphonic acid), which possesses both a thiol group for cytoprotection and a highly polar sulphonic acid group, and results in high renal excretion and delivery of this cytoprotective molecule to the bladder epithelium

Some individuals may experience mild digestive discomfort or skin rashes