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If you experience any unusual or severe symptoms after taking your injection early, particularly severe or persistent upper abdominal pain (which may radiate to your back), with or without vomiting, seek urgent medical help as this could indicate pancreatitis

The exploration of combination strategies, such as GLP-1 RAs with setmelanotide in patients retaining partial MC4R function, may offer additive benefits by targeting both MC4R -dependent and MC4R -independent pathways

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