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Bupropion has minimal interaction with metformin, making a three-drug combination of bupropion, metformin, and tirzepatide generally manageable under medical supervision

If more than 12 hours have passed, skip that dose and take your next dose at the regular time the following day

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[DOI] [PMC free article] [PubMed] [Google Scholar] 1763.Carstensen B, Read SH, Friis S, et al

The safest approach is increasing potassium through food sources first, then supplementing conservatively if needed, always under medical guidance