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Connell, E

Average weight loss appears greater with retatrutide in early studies, but individual response depends heavily on genetics and baseline metabolic function

C.MonzonS.CuestaI.PelaezT.et al

[1] [2] These medications enhance insulin secretion in response to meals, suppress glucagon release, slow gastric emptying, and reduce appetite through central nervous system pathways

A similar clinical trial using an older GLP-1 medication found that, in a cohort of 200 patients, those receiving the drug showed 18% slower cognitive decline and 50% slower shrinkage of the brain over a year