Patients entered a 2-week, single-blind run-in treatment period on pre-mixed, long-acting, or intermediate-acting insulin, with or without metformin HCl (1500 mg per day)
Researchers found that patients taking Wegovy were approximately five times more likely to develop ischemic optic neuropathy compared to people using other diabetes medications
Barbieri M, Bonafe M, Rizzo MR, Ragno E, Olivieri F, Marchegiani F, Franceschi C, Paolisso G
As early as the 1930s, over-the-counter pills such as Dinetrophenol were acting on the thyroid, with real resultsbut also significant side effects, like cataracts and death by hyperthermia
A structured reset with a different formulation or dosing strategy sometimes restores responsiveness
Evidence in PsA is preliminary but suggests potential benefits of GLP-1RAs in disease activity modulation