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10.1038/tp.2015.68 53 ThomsenM.DenckerD.WortweinG.WeikopP.EgeciogluE.JerlhagE.et al (2017)

Specifically, the HFD group exhibited significant upregulation of genes encoding key enzymes involved in de novo lipogenesis (e.g., Fasn , 3.76-fold), fatty acid elongation ( Elovl1 , 2.20-fold), and desaturation ( Scd2 , 3.33-fold)

With regard to comorbidity, it is important to note that hyperuricemia and gout may coexist with other accompanying conditions, such as diabetes mellitus, obesity, metabolic syndrome, and hypertension, highlighting the important multidisciplinary approach, required for their management