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These combined effects may explain why cardiovascular outcomes improve even when cholesterol values shift only modestly

However, while there are some promising links, the evidence directly connecting semaglutide to back pain relief is still limited

Semaglutide inhibits glucagon, a hormone that increases blood glucose levels by stimulating the liver to convert stored glycogen into glucose

3 One study (an extension of the original STEP-1 trial) also showed that participants regained two-thirds of their weight after discontinuing semaglutide, suggesting that maintaining weight loss may require long-term use

Neither semaglutide nor tirzepatide has a clinically significant safety advantage over the other, though nausea and gastrointestinal effects occur in both

became the first drug maker approved by Health Canada to sell a generic version of Ozempic