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Description

Long-term toxicity Continuous injection of AOD 9604 (10 mg/kg) for 8 weeks did not cause abnormal liver and kidney functions or fluctuations in blood glucose

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This immune response leads to inflammation and destruction of the cells, ultimately resulting in reduced or complete loss of insulin secretion, culminating in hyperglycemia that progressively manifests as diabetes [2]

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Buhr ED, Takahashi JS (2013) Molecular components of the mammalian circadian clock

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