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The DMF is considered as a prodrug, after oral administration, rapidly hydrolyzed by esterases in the small intestine and converted to MMF representing an intermediate of tricarboxylic acid cycle (TCA) (7)

But the gap between "berberine has some evidence when swallowed at 1,500 mg" and "a patch with 8.75 mg of berberine will help you lose weight through your skin" is a canyon, and the marketing fills that canyon with aspiration rather than data

ISBN 978-1-60913-345-0

Chaudhary A, Maurya PK, Yadav BS et al (2018) Current therapeutic targets for Alzheimers disease

H., Jeon, Y