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A 2016 study in Cellular and Molecular Gastroenterology and Hepatology showed that KPV dramatically reduced colonic tumorigenesis in a model of colitis-associated cancer an effect that was abolished in PepT1-knockout animals

Once enrolled in the DAPA-HF trial, adult patients were not required to discontinue therapy if eGFR fell below 30 mL/min/1.73 m2 or if dialysis was initiated [see Dosage and Administration (2.3) and Clinical Studies (14.4,14.5)]