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Intervention with the therapeutic drug, amifostine (AMI), can reduce DNA damage and ROS levels in cells and the ratio of RANKL to OPG, inhibit the maturation and differentiation of osteoclasts, and has a bone protective effect (222).Osteoclasts cause ROS accumulation during bone resorption or increased RANKL expression (223)

Analyses of results from cardiovascular safety trials with DPP-4 inhibitors: Cardiovascular outcomes, predefined safety outcomes, and pooled analysis and meta-analysis

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Its use sits far ahead of other options like IUDs or emergency contraception

331 These findings are in agreement with the results of an earlier meta-analysis of the PD gut microbiome

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