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Why might GLP-1 medications need to be paused before surgery

The same label carries a warning: "There have been rare postmarketing reports of pulmonary aspiration in patients receiving GLP-1 receptor agonists undergoing elective surgeries or procedures requiring general anesthesia or deep sedation who had residual gastric contents despite reported adherence to preoperative fasting recommendations." That is the whole reason for a pre-surgery pause with GLP-1 medicines

The idea is that stacking two different satiety pathways gives better results than either alone

Given the complex interplay between sex hormones like estrogen and progesterone and GLP-1 efficacy and tolerability, an individualized approachpotentially guided by emerging AI clinical modelsis essential to optimize dosing

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