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Even though there are studies showing an effective and safe reduction of glycaemic parameters with initial combination therapies with DPP-4 inhibitors, initial combinations are not generally recommended in the new treatment recommendations (85)

Diabetes Care 37, 21592167

Scheen AJ, Lefbvre PJ

biologically effective amounts are amounts of VEGFR2-blocking, human anti-VEGF antibodies of the invention effective to inhibit VEGF-induced lymphangiogenesis i.e., VEGF-A stimulated lymphangiogenesis induced by VEGFR2

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