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Companys-Alemany J, Turcu AL, Schneider M, Muller CE, Vazquez S, Grinan-Ferre C, et al

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It may be hypothesized that in hyperuricemic subjects, UA-lowering drugs may be beneficial in preventing diabetes

502,503 Of note, ITI-214, a specific PDE1 inhibitor, has been well-tolerated by humans and a phase 2 clinical trial for heart failure has been completed