Combining biomarker and imaging endpoints could determine whether combination therapy enhances plaque stabilization and cardiovascular protection
The SURMOUNT-1 trial of tirzepatide reported 4.3-7.1% across dose groups
Prescriptions are based on patient eligibility, and patient-specific compounding needs
Participants consumed significantly more fat (% of total calories), saturated fat, linoleic acid, alpha-linolenic acid, selenium, sodium, riboflavin, niacin, and vitamin B12 than the DRI
Semaglutide showed the same improvements in gene expression of key mitogenic genes such as Drp1, OPA1, Fis1, and others [153]
After implementing some of these strategieseating smaller, more frequent meals, avoiding high-fat foods, and using a short course of anti-nausea medication during dose increasesthey found their nausea became much more manageable