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10.1128/mbio.02310-24 7 CalabreseC.PanuzzoC.StangaS.AndreaniG.RaveraS.MaglioneA.et al (2020)

25 The Val 23 and Ile 27 used in tirzepatide are likely to have little impact on either GLP-1 or GIP activity because they are the same kind of residue and no specific interaction in these sites has been detected

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These meds work by reducing blood sugar levels, which helps regulate metabolism in people dealing with these health issues