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Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth

Discovery of a potent and oral available complex I OXPHOS inhibitor that abrogates tumor growth and circumvents MEKi resistance

BPC-157 and MOTS-c have both been flagged by the FDA for potential safety concerns, and both appear on WADAs list of banned substances (the organization that oversees drug testing in competitive sports)

doi: 10.1128/JVI.02520-12 261 SinghM.Barrera AdameO.NickasM.RobisonJ.KhatchadourianC.VenketaramanV

Son rle physiologique est clairement tabli : elle participe au transport des acides gras vers les mitochondries, les structures cellulaires impliques dans la production nergtique

18,19,20,21 Finally, IL-17 and IL-8 (CXCL8) promote inflammation, recruitment and activation of neutrophils and increased levels have been found in autoimmune diseases such as systemic lupus erythematosus, inflammatory bowel disease and psoriasis