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With regards to dosing, oxymetazoline HCl is dosed on the basis of the HCl salt and brimonidine tartrate is dosed on the basis of brimonidine rather than the tartrate salt.6,7 Both APIs have pH stability in the slightly acidic range and have aqueous solubility, though, brimonidine tartrate has pH related solubility, with increasing solubility at acidic pH.6, 11,12 Oxymetazoline HCl has demonstrated physical compatibility with Versatile and Nourivan Antiox at up to 2% and compatibility with Cleoderm at up to 1%

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