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Immunohistochemical staining indicated the presence of GLP-1R at the membrane and cytoplasmic levels in both chondrocytes and macrophages

While traditionally recommended for short-term use, some patients may require longer-term supervised use as part of a bowel management plan

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We examined in particular: Bos taurus ( n =40), Sus scrofa ( n =18), Capra hircus ( n =20), Equus caballus ( n =14), Equus asinus ( n =14) and Ovis aries ( n =15)

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Half of them were given a placebo while the other half took semaglutide, the active ingredient in Ozempic and Wegovy, for 16 weeks