lfod14 2024-08-22 21:01:01 UTC #6 From playing with the dosages a lot over the last year or two, seems the 0.25mg is pretty much the lowest dose where you can actually notice it working, you can adapt pretty quickly, especially if you follow the dosage guidelines, but for appetite suppression, you definitely dont need to ramp the dose up like youre supposed to, for a while when I upd to 0.25mg/2xwk which kept the suppression down better after I originally adapted
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doi:10.1161/CIRCRESAHA.109.198366, PMID: 19910579 Starkov AA, Fiskum G, Chinopoulos C, Lorenzo BJ, Browne SE, Patel MS, Beal MF (2004) Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species
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