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GHK-Cu carries copper, so prolonged exposure is a reasonable research concern

469 Finally, two recent studies have demonstrated that two surrogate markers of oxidative stress, oxLDL 470 and plasmalogen 471 were associated with increased cardiovascular mortality in patients with advanced CKD

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Open questions in the GHK-Cu field include the specific cellular targets responsible for the broad transcriptomic effects, the relationship between the copper-delivery role and the direct peptide-only effects (if any), the comparative biology of GHK-Cu and related copper-peptides in defined cellular contexts, and the translation of cell-culture and animal-model findings to clinical-research endpoints under controlled study conditions

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These results suggested that MrGST1 participated in anthocyanin transport and may have functions differently from TT19 during seed-coat coloring