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During SARA, rapid microbial fermentation leads to the accumulation of lipopolysaccharide (LPS) and histamine, which downregulate tight junction proteins and increase epithelial permeability, thereby compromising the structural integrity of the ruminal epithelial barrier 52

They are water-soluble and not stored in the body so regular consumption is required

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Since GSH synthesis contained two ATP-consuming reactions, the supplement of ATP became one of the major factors which affected the GSH production

Dysregulated signaling pathways such as Wnt/-catenin, TGF-, and PI3K/Akt have been shown to modulate osteoblast and osteoclast activity in OA subchondral bone