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Due to this hyper-responsiveness of the immune system during hyperthyroidism, it is plausible that uncontrolled hyperthyroid patients, especially with thyrotoxicosis, may be at higher risk of complications from any infection (42)

Key Points: - Efficacy: Participants taking Orforglipron experienced weight loss up to 11.2% at a 36 mg dose, compared to a 2.1% reduction in the placebo group

Proposed mechanisms include: DSIP-induced upregulation of downstream receptor systems that outlast the peptide itself

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