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LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors

doi: 10.1016/j.schres.2013.05.018 145 PresumeyJBialasARCarrollMC

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Multiple mechanisms have been identified, including secondary KRAS mutations, activation of receptor tyrosine kinases such as EGFR and MET, bypass signaling through NRAS and HRAS, and reactivation of the MAPK pathway