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This process, known as central sensitization , occurs when the nervous system remains in a heightened threat or stress state

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Inhibition of Nrf2 enhanced the sensitivity of RTECs to ferroptosis caused by high glucose, and upregulating Nrf2 reversed the expression of ferroptosis-related proteins to ameliorate cell injury under high glucose conditions[88]

It lingers

Back to work: Right after the therapy

Science 300(5622):11421145