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UK regulatory guidance (MHRA, NICE, BNF) advises against GLP-1 use whilst breastfeeding owing to lack of robust human safety studies

Consequently, clinicians can prescribe these treatments with greater confidence

Across all GLP-1 medications, 12-month persistence (still taking the medication at one year) ranges from 38% to 56% depending on the study and population (Wilding et al., Diabetes Obes Metab 2023)

One of the advantages Holst's group had in working on the issue was that researchers in Copenhagen were skilled at keeping pancreases alive that had been removed from pigs by perfusion with artificial blood

The assumption of proportional hazards was evaluated with the generalized Schoenfeld approach on the TriNetX platform, with aHRs recalculated for specific time frames if initial assumptions were not met

Eating small, regular mealseven when appetite is suppressedstabilizes blood sugar and reduces headache frequency