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72 In humans with class 1 obesity who display microvascular insulin resistance in both skeletal and cardiac muscle microvasculature, GLP-1 at physiological concentrations remains effective in increasing skeletal and cardiac microvascular perfusion

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30 minutes4 hours) reflects receptor desensitization and neuromuscular blockade, leading to central nervous system depression, bradycardia, hypotension, respiratory muscle paralysis, and potential respiratory failure

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