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Notably, given that SGLT-2 is expressed in the brain, which is consistent located with enhanced cFos expression induced by SGLT-2is, we hypothesize that SGLT-2is may cross the BBB via receptor-mediated transcytosis

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Long-term support may include nutrition, protein planning, resistance training, sleep support, behavior changes, and medical follow-up

Ferroptosis is involved in the development of neuropathic pain and allodynia

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They are soft, painful, hyperpigmented plaques and sometimes have excessive hair (hypertrichosis)