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Some surface-modification approaches introduce additional challenges

Telomerase, also known as terminal transferase, is a ribonucleoprotein adding a species-dependent telomere repeat sequence to the 3end of telomeres

This effect typically resolves as the body adjusts to altered metabolic signaling

The change in body weight from baseline to week 68 was 15.3 kg in the semaglutide group as compared with 2.6 kg in the placebo group (estimated treatment difference, 12.7 kg