We have recently generated a transgenic mouse line that allows for tissue-selective expression of the endogenous Gcg gene [9]
The arcuate nucleus (ARC) is located near the floor of the third ventricle and the median eminence with a fenestrated epithelium that facilitates hypothalamic sensing of peripheral metabolites and hormones [1, 2] including insulin, serotonin, leptin, and nutrients such as glucose and free fatty acids [35]
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