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Notably, the knockout of the IL6 receptor in adipose cells did not negate the anti-obesity effect of liraglutide, indicating that GLP1RA signaling in the CNS may be more important for weight loss [36]
In neurodegenerative disorders such as Alzheimers and Parkinsons diseases, alpha-lipoic acid has gained attention for its ability to reduce the accumulation of misfolded proteins within mitochondria (via mtUPR), as well as mitigate the excessive production of ROS, protecting neurons against mitochondrial dysfunction [75, 76]
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There are also National Institute of Clinical Excellence (NICE) approved digital providers of wrap-around care to support prescribing of GLP-1RA [4]
Geva, R
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