It works through several mechanisms, such as suppressing appetite, increasing satiety, reducing food cravings and feelings of hunger, and delaying gastric emptying (the rate at which the stomach empties)
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Certain tumors escape ferroptosis by upregulating system xc (a cystine/glutamate antiporter composed of SLC7A11 and SLC3A2) or glutathione peroxidase 4 (GPX4), a key enzyme that reduces lipid hydroperoxides and protects cells from ferroptotic death [1]
72 Although based primarily on anecdotal and case reports, concerns regarding risk of regurgitation and pulmonary aspiration due to delayed gastric emptying have resulted in guidance from the American Society of Anesthesiologists (ASA) Task Force on Preoperative Fasting for use of these medications prior to non-urgent or emergent procedures requiring general anesthesia
