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Results While GLP-1 and GIP agonists demonstrate significant metabolic benefits, their long-term use is often limited by gastrointestinal side effects and psychological impacts

2.2 Mood-stabilizers 2.2.1 Lithium The role of PKC in the pathophysiology of bipolar disorder was suggested in 1994 by Manji and colleagues after observing that chronic lithium use has PKC-dependent transcriptional and posttranscriptional effects involving long-term neuroplasticity and cellular response

IL-12 and IL-23 pathway inhibition in inflammatory bowel disease

3.2 Melanin-synthesis-inhibiting peptides of plant origins 3.2.1 From pseudostellaria heterophylla In a 1994 study in Japan, seven cyclic peptides were extracted from the roots of Pseudostellaria heterophylla , all of which exhibited inhibitory activity against mushroom tyrosinase

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doi: 10.1007/s00125-011-2069-9 39 TamuraKMinamiKKudoMIemotoKTakahashiHSeinoS