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Phosphatidylinositol-3 kinase (PI3K) is a key regulator of the activation of the mammalian target of rapamycin (mTOR), which is considered an important regulator upstream of the ATG gene

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Genetic factors influencing GLP-1 receptor and glucose-dependent insulinotropic peptide (GIPR) sensitivity can provide context for expected responsiveness, though genetics alone does not determine outcomes

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