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Before we give you a possible time frame to expect your B12 shot to work, consider your relationship with B12

You take metformin or a proton pump inhibitor, which can deplete B12 over time

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These drawbacks are common to all injections, however, not just vitamin B12

How to Reduce Injection Reactions Rotate injection sites consistently Allow peptides to reach room temperature before injecting Inject slowly using a fine-gauge needle Avoid rubbing the site after injection Split larger doses into multiple sites if needed Some patients experience fewer reactions with intramuscular injections

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