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When combined with GLP-1 receptor agonists, probiotics may synergistically enhance weight loss outcomes

A few hundred extra calories per day adds up to maintenance or slow regain

A dedicated phase 2a substudy in people with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) used MRI to measure liver fat and found that, after 24 weeks, retatrutide reduced relative liver-fat content by about 81% at the 8 mg dose and about 82% at 12 mg, versus essentially no change on placebo

The difference is approximately 8 percentage points, which translates to roughly 20 additional pounds lost for a 250-pound individual

Starting the Low FODMAP Diet. Monash FODMAP, Accessed 14 May 2026

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