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A pronounced depletion of beneficial short-chain fatty acid (SCFA)producing genera including Prevotella , Faecalibacterium prausnitzii , and Roseburia is a recurrent feature across cohorts

These pathways include the regulation of the tricarboxylic acid (TCA) cycle, aerobic glycolysis and fatty acid (FA) synthesis, which are crucial for tumour cell survival and proliferation (30,31) and also affect the stromal and immune cell components of the tumour microenvironment (32)

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