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Because the body has to process a large amount of the supplement at once, the digestive tract can sometimes become slightly irritated

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Its predictable degradation profile, stability, and reproducibility make it suitable for complex experimental designs

Genetic polymorphisms in genes encoding matrix metalloproteinases, collagen synthesis enzymes, or inflammatory mediators could theoretically influence GHK-Cu responsiveness, though systematic investigations of pharmacogenetic determinants remain absent from current literature