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Owing to its high concentration in the cell (~10 3 M) 1 , the GSH/GSSG pair acts as the main intracellular redox buffer, plays a key role in the detoxification of reactive oxygen species (ROS), and participates in redox signalling 2
However, there are reasons to be optimistic about the future
It reverses the cell damage caused by fatty liver disease Cell death in the liver is aggravated by a deficiency in antioxidants, including glutathione
Additionally, the ghrelin receptor is abundantly expressed in somatotrophs of the pituitary gland, supporting the role of ghrelin in regulating GH release
Renal function decline as GLP-1 and GIP agonists can cause nausea, diarrhoea and vomiting, this may result in dehydration and associated reduction in renal function