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Zepbound Outperforms Wegovy in Head-to-Head Weight Loss Trial In a 72-week clinical trial, tirzepatide (Zepbound) led to significantly greater weight loss than semaglutide (Wegovy), with participants losing an average of 20.2% of their body weight versus 13.7%

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They found that treating 67 diabetes-free overweight or obese patients at high risk of a cardiovascular event for 40 months would prevent one major cardiovascular event, such as heart attack or stroke, or death due to heart disease

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This pricing model removes the financial incentive to skip doses, making weekly injections more accessible than stretching expensive brand-name vials

Study end points The primary endpoint was the percentage of total body weight loss (TBWL%) at 12 months after semaglutide initiation by HT use