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PMID: 35955624 Int J Mol Sci2022 Aug 15;23(16):9134

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For example, one study found that a significant decrease in the abundance of F

Fourth, LC affects endothelial cells, disrupting the VEGF/VEGFR2 and CXCR4/CXCL12 axes and lowering angiogenesis in vitro

The intrinsically disordered interdomain region between the helicase and nuclease domains of an archaeal Hef protein from Thermococcus kodakarensis was shown to be involved in interactions with multiple proteins including PCNA1 and a RecJ-like protein, suggesting that Hef acts as a scaffold and uses this IDR for sequential interaction with several proteins to control the repair pathway at the stalled fork (Ishino et al., 2014)