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If your skin feels uncomfortable or red, stop using the product

Patients with prior thrombosis, thrombophilia, or cancer require individualized risk assessment and may benefit from additional monitoring or alternative therapy

Stress and high cortisol levels have the opposite effect to melatonin, prolonging sleep onset and leading to increased sleep fragmentation [50]

When to contact your GP: Persistent severe nausea or vomiting that prevents adequate fluid intake Signs of dehydration (dizziness, dark urine, reduced urination) Severe abdominal pain that could indicate pancreatitis Symptoms of very low blood sugar (confusion, sweating, trembling) if taking other diabetes medications Blood pressure readings consistently below 90/60 mmHg or above your target range Blood pressure readings of 180/120 mmHg or higher, especially with symptoms such as severe headache, chest pain, or vision problems (seek same-day medical assessment) Any new or concerning symptoms Your healthcare team may adjust your blood pressure medications if your readings improve significantly

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Although uncommon, discussing any concerns with your healthcare provider can help you be prepared