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453 Interestingly, Nrf1 is downregulated in PD, suggesting that Nrf1 upregulation may alleviate impaired protein turnover, thereby reducing proteotoxicity and enhancing neuronal resilience against PD pathogenesis

Wang YT, Linden DJ (2000)

That said, clinical trial results in Parkinsons disease have been mixed

BP labeling of the yeast library was followed by streptavidinfluorophore staining and fluorescence-activated cell sorting (FACS) to enrich populations with high activity

Based upon a review of 59 reported cases of accidental EpiPen finger injections (Fitzcharles-Bowe et al, 2006), finger necrosis appears unlikely (0 cases of necrosis out of 59 case reports reviewed)