As a result, methylation may be disrupted
While highly effective, gastrointestinal side effectsparticularly constipation (10-24%), nausea (17-31%), and diarrhea (12-23%)are common due to slowed gastric emptying
[DOI] [PubMed] [Google Scholar] 122.Fucic A., Guszak V., Mantovani A
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This process is mediated by glutaredoxins (GLRXs, also known as GRXs), which catalyze both glutathionylation and deglutathionylation, as well as by sulfiredoxins (SRXs) 9,10
The gut-joint axis: microbial dysbiosis and OA Emerging evidence firmly establishes a link between gut microbiota dysbiosis and OA progression, primarily mediated by microbial metabolites via the gut-joint axis. The core protective mechanism involves short-chain fatty acids (SCFAs) like butyrate and propionate, produced from dietary fiber fermentation by commensals such as Bacteroides and Faecalibacterium prausnitzii