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[7] Two trials in the phase 3 TRIUMPH program reached primary completion in April 2026: TRIUMPH-1, a master protocol in adults with obesity or overweight, and TRIUMPH-3, in participants with severe obesity and established cardiovascular disease

These data indicated that berberine activated GLP-1/GLP-1R/PKA signaling pathway in STC-1 cell

Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation

Evidence level is high

The approval was backed by data from the Phase II TRANSCEND FL study in which treatment with the CAR T cell therapy led to a 95.7% overall response rate, with a complete response rate of 73.4%

In gallbladder cancer tissues, the accumulation of acylcarnitine not only provides an additional energy source for tumor cells, but also promotes tumor cell proliferation and migration by activating the phosphorylation of JNK