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Efficacy and safety of once-weekly efpeglenatide in people with suboptimally controlled type 2 diabetes: the AMPLITUDE-D, AMPLITUDE-L and AMPLITUDE-S randomized controlled trials

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In the SURMOUNT-1 trial for tirzepatide, the highest dose produced average weight loss exceeding 20% of body weight, with older participants showing results comparable to the overall trial population

Children arent spared

This result agrees with the finding of Alachkar et al

Similarly, adenosine receptor knock-out mice did not exhibit any defects in sleep homeostasis (Stenberg et al