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Minimizing Risk for Cardiovascular Diseases ASCVD (atherosclerotic cardiovascular disease) is a significant cause of morbidity and mortality in individuals with diabetes

PIONEER Trials : These trials evaluated oral GLP-1 therapy, demonstrating similar cardiovascular benefits as its injectable counterpart

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However, research on related GLP-1 analogs suggests these drugs can affect visceral sensitivity and motility, with some studies (e.g., on ROSE-010) showing short-term reductions in IBS-related abdominal pain in certain participants

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