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52 In a large meta-analysis by Chiang et al involving 106,395 participants and 55 RCTs, GLP-1 RA therapy was associated with an increased risk of gastroesophageal reflux disease (GERD) compared to placebo, with a reported relative risk of 2.19 (95% CI: 1.483.25)

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We then tested whether other agents that specifically caused nucleotide imbalance (rather than the DNA-driven and RNA-driven effects of 5FU) have the same mechanism of action

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